Enrichment of intersubtype HIV-1 recombinants in a dual infection system using HIV-1 strain-specific siRNAs
نویسندگان
چکیده
منابع مشابه
Intersubtype Recombinant HIV-1 Sequences
Retroviruses are highly recombinogenic, but recombination can only occur between genomes packaged within the same virion. Until about 1994, it was generally thought that individuals do not become infected with multiple distinct HIV-1 strains, and so the possibility that recombination between divergent viruses could contribute to the evolution of HIV-1 was not widely considered. However, not lon...
متن کاملHigh Prevalence of HIV-1 Intersubtype B′/C Recombinants among Injecting Drug Users in Dehong, China
OBJECTIVE To examine the distribution of HIV-1 genotypes among injecting drug users (IDUs) from Dehong, Yunnan province. MATERIALS AND METHODS Blood samples from a total of 95 HIV-positive IDUs were retrospectively analyzed. Samples were collected between 2005 and 2009 from four cities in Dehong prefecture, western Yunnan province, the geographical origin of the HIV epidemic in China. HIV-1 g...
متن کاملIntersubtype Recombination in HIV-1 and HIV-2
Recombination has long been known to represent an important means by which retroviruses generate genetic diversity. Each retrovirus particle contains a dimeric RNA genome and a reverse transcriptase enzyme that can switch templates during proviral DNA synthesis. Several mechanisms have been proposed to explain the recombination process, all of which are believed to operate during the reverse tr...
متن کاملCharacterization of Novel HIV-1 Intersubtype CRF01_AE/C and A1/C Recombinants from India
We report here three novel HIV-1 intersubtype recombinants from India. One among those is a recombinant between subtype C and CRF01_AE and another two between A1 and C. A recombinant virus with CRF01_AE is reported for the first time from India.
متن کاملEvaluation of clinical course and laboratory findings in HIV/HTLV-1 co-infection compare with HIV mono infection
Background: In the last 10 years, co-infection of human immunodeficiency virus/human T-cell leukemia virus-1 (HIV/HTLV-1) has emerged as a worldwide health problem. These viruses has the same route to infect human but different effects on CD4 positive T-cells. There was controversial results about the influence of co-infection HIV/HTLV-1 pathogenesis. This study compared clinical course and lab...
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ژورنال
عنوان ژورنال: Retrovirology
سال: 2011
ISSN: 1742-4690
DOI: 10.1186/1742-4690-8-5